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One of the breakdown products (metabolites) of epinephrine (adrenaline) and norepinephrine is vanillylmandelic acid (VMA). Both epinephrine and norepinephrine are members of a class of hormones known as catecholamines. To find excessive levels of epinephrine and norepinephrine, this test examines the quantity of VMA that is passed into the urine, typically over a 24-hour period. It is used to identify neuroendocrine tumours such as neuroblastomas. The adrenal medulla, which is located in the middle of the adrenal glands, is where catecholamines are made. The small, triangular adrenal glands are situated above each kidney. Dopamine, epinephrine and norepinephrine are the main catecholamines secreted.
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