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Adrenaline, Noradrenaline, Dopamine are catecholamines present in plasma at low concentrations. Less than three fold elevation of catecholamines are observed in individuals with Essential Hypertension. Greater than threefold levels of catecholamines of persistent or of episodic nature are observed in Pheochromocytoma. Drug related variance in catecholamine levels are seen in individuals on alpha methyl dopa,methenamine mandelate and labetalol.Discontinuation of these medications one week prior to catecholamine assay ensures accuracy of the results. Interference in catecholamine assay due to synthetic catecholamines analyses e.g. isoproterenol and isoetharine needs correlation with clinical inputs. In individuals with clinical signs and symptoms of pheochromocytoma with normal catecholamine levels,evaluation of 24 hour urinary catecholamines or urinary metanephrine is recommended; to rule of possibility of episodic elevation in plasma catecholamine levels.
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